Technician B Job at Columbia University Medical Center

Columbia University Medical Center New York, NY 10032

534443

Medical Center

Microbiology and Immunology

Full Time

Opening on: Mar 9 2023

Technical Grade 4

Job Type: Support Staff - Union

Bargaining Unit: SSA

Regular/Temporary: Regular

End Date if Temporary:
Hours Per Week: 35

Salary Range: $50,329.13 - $50,329.13

The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training. The above hiring range represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting.

Position Summary

The Department of Microbiology & Immunology at the Columbia University Irving Medical Center seeks a dynamic Technician B with a background in biological research to join a vibrant research lab that conducts research into malaria. The research technician will play a key role in our investigations into mechanisms of Plasmodium falciparum parasite resistance to antimalarial drugs.

Responsibilities

ESSENTIAL FUNCTIONS

Parasite culture work - 55%

Molecular biology – 20%

Data analysis - 15%

Related duties as assigned - 10%

Contact with

Blood-borne pathogens ( Plasmodium falciparum , routine Biosafety Level 2 precautions)

Chemicals (non-toxic)

The work will involve assessing resistance liabilities for antimalarial compounds in the preclinical stages of discovery or development. Specifically, this will include culturing malaria parasites, performing drug dose-response assays, generating drug-resistant parasites, sequencing target genes, and interpreting whole-genome sequence data. This work is supported by Medicines for Malaria Venture, a Geneva-based not-for-profit organization that leads the global antimalarial discovery and development pipeline.

The technician will also be involved in projects to genetically map drug resistance traits in parasites through genetic crosses between multidrug-resistant and -sensitive parasites. This project is supported by the National Institutes of Health and the Bill & Melinda Gates Foundation. In this capacity, the technician will be responsible for propagating cross progeny, testing their clonal integrity, conducting drug susceptibility assays with the progeny and parents, and helping assemble genetic maps to positionally locate the resistance-conferring genes. The goals are to define genes that mediate resistance to antimalarial drugs used clinically in Southeast Asia, where parasite resistance is widespread.

Both projects are collaborative studies involving postdoctoral scientists, graduate students, research technicians and the group leader Dr. David Fidock working as a tightly integrated team. The technician will also assist with general lab management including exchanging materials with outside collaborators and ensuring equipment is regularly serviced and maintained. The technician will also be responsible for assuring that reagents related to their work are properly stored and cataloged and will help with overall lab management.

This position offers the opportunity to be involved in cutting-edge research into defining the genetic basis of drug resistance for a disease that has a vast impact on the tropical regions of the world (with over 240 million cases and 619,000 deaths yearly, mostly affecting African children younger than five).

The hired research technician will work in a vibrant environment of ~18 researchers recruited from around the world. Our group is well-funded, very interactive, and highly productive in publications per year. Our research technicians typically continue into Ph.D., MD, or MD/Ph.D. programs upon having completed two years of research in the lab. We seek applicants who are highly motivated, self-sufficient, interactive, detail-oriented, passionate about infectious diseases research and global health, and who enjoy genetics and cell biology research.

Minimum Qualifications

Bachelor’s degree in Chemistry, Biology, Physics, or related science, or equivalent in education, training and experience.

Preferred Qualifications

Research experience and technical proficiency in molecular biology and/or cell culture is preferred but not essential.

One year of related experience preferred.

Master’s degree is preferred but not essential.

Other Requirements

Must have undergraduate university coursework in molecular biology, biochemistry, microbiology or genetics.

Equal Opportunity Employer / Disability / Veteran

Columbia University is committed to the hiring of qualified local residents.


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