The primary responsibilities of the in vivo pharmacology Scientist II/Sr. Scientist will be to develop pre-clinical small animal rare genetic disease models and plan/conduct in vivo pharmacology experiments to characterize the function and efficacy of novel engineered human B lymphocyte cell therapies. The incumbent will also support ex vivo analyses and will be responsible for summarizing and presenting in vivo research data to key stakeholders within the research organization. This position will require deep cross-functional collaboration within Be Biopharma, as well as with external collaborators and CROs. The successful candidate will have the opportunity to contribute to projects across therapeutic areas and oversee studies run with external partners.

Job Responsibilities

• Lead the development of novel small animal models of rare monogenetic diseases and coordinate with external partners to generate the model, develop breeding plans and design associated pharmacology studies.
• Conduct in vivo (mouse) studies to characterize and assess the engraftment, function, PK and biodistribution of gene engineered human B cell products.
• Hands-on work will include dosing of mice (intravenous, oral or intraperitoneal) and isolation and processing of small animal (mouse) blood or tissues.
• Support the development of new in vivo models including, but not limited to, transgenic mouse models, live animal bioluminescent or fluorescence imaging and in vivo target discovery models.
• Excellent experimental design, troubleshooting, and data analysis skills are required.
• Great communication skills and team spirit is essential, and the ability to communicate results within research organization and at project team meetings required.
• Work in a closely integrated team to organize and execute studies involving novel gene edited B cell product.

Minimum Experience, Education, and Specialized Knowledge and Skills:

Must thrive in a fast-paced, growing, and innovative environment where flexibility, resourcefulness, resiliency, and communication skills are key. Excellent interpersonal skills, ability to develop important relationships with your stakeholders, and being an all-around good company citizen are essential!

• BS, MS or Ph.D. degree in Biology, Pharmacology, Immunology, Immune-Oncology or related field with a track record of delivering high quality research (title commensurate with experience)
• 2+ years relevant experience in biopharmaceutical, biotechnology industry, or translational academic environment
• Demonstrated ability to work efficiently both independently and in a team environment
• Proven ability manage CROs as well as design and run studies
• Demonstrates scientific creativity, critical thinking, ability to innovate, and analytical problem solving
• Cross-functional management of the in vivo experiments and being able to make snap decisions to modify study designs
• Ability to present complex experimental details to a large group and seek out and incorporate feedback on experimental design